Why the study?
Whether smaller pancreatic volume and lower beta-cell mass in type 2 diabetes are causes or consequences of the disease remains unclear.
Population
Individuals across a PET/CT study, UK Biobank cohort (N = 25,212), and case-cohort study (N = 2168)
Comparison
Four groups classified by median pancreatic volume and intrapancreatic fat deposition
Design
Multimodality imaging, cross-sectional, and case-cohort study
Follow-up
6-year
Authors
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Pancreatic volume and IPFD associations with beta-cell function in T2D remain hypothesis-generating; leaves open causality and clinical relevance.
The combination of a small pancreas and high intrapancreatic fat deposition is a structural phenotype strongly associated with an increased risk of developing type 2 diabetes.
Yamazaki et al. (2026) studied this question.
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