Population
P2Y13R(-/-) mice and ovariectomized P2Y13R(-/-) mice
Comparison
Deletion of the P2Y13 receptor (genetic knockout) vs Wild-type mice
Design
Preclinical
Authors
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P2Y13 may be a target to limit estrogen deficiency bone loss; leaves open clinical translation in humans.
Deletion of the P2Y13 receptor reduces bone turnover rates and protects against estrogen deficiency-induced bone loss in mice.
Wang et al. (2011) studied this question.
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