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This clinical trial evaluates the effect of a polyphenol-rich ingredient on body composition management in 77 overweight and obese, but otherwise healthy, men and women for 16 weeks and 4 weeks of follow-up. Subjects received a placebo or a polyphenol-rich ingredient (Sinetrol® Xpur) at a dose of 900 mg/day. Participants followed a normocaloric diet and continued with their usual physical activity during the study. Total fat% significantly decreased by 1.98% (SD 3.5) in the polyphenol-supplemented group after 16 weeks compared to the placebo group. This decrease was accompanied by a trend (p = 0.06) towards an increase in lean mass compared to the placebo group and an increase in Resting energy expenditure (p = 0.02) within the polyphenol-supplemented group. All the safety parameters were within normal ranges and no adverse effect was noticed. Overall, this 16-week supplement intake might have contributed to body composition management and may help prevent the regain of fat during the 4-week follow-up.Trial registration number: NCT04149158
Muralidharan et al. (Mon,) studied this question.