Safety and efficiency of ventricular pacing prevention with an AAI-DDD changeover mode in patients with sinus node disease or atrioventricular block: impact on battery longevity—a sub-study of the ANSWER trial
Why the study?
Does SafeR mode reduce ventricular pacing and improve device longevity compared to DDD mode in patients with sinus node disease or atrioventricular block?
Population
632 patients implanted with a dual-chamber pacemaker for atrioventricular block or sinus node dysfunction
Comparison
SafeR mode (AAI-DDD changeover mode) vs DDD mode
Design
RCT, randomly assigned
Follow-up
36 months
Authors
Discussion
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Member takes
Overview
SafeR may reduce anticipated replacements in SND and intermittent AVB; leaves open whether it alters device selection in practice.
Structured PICO
Does SafeR mode reduce ventricular pacing and improve device longevity compared to DDD mode in patients with sinus node disease or atrioventricular block?
P
Population
632 patients implanted with a dual-chamber pacemaker for atrioventricular block (AVB, n=310) or sinus node dysfunction (SND, n=336)
I
Intervention
SafeR mode (AAI-DDD changeover mode)
C
Comparator
DDD mode
O
Outcome
Safety (mortality, syncope, mode intolerance), median ventricular pacing (VP), estimated device longevity, and anticipated replacement ratessurrogate
The SafeR pacing mode significantly reduces unnecessary ventricular pacing in patients with intermittent AV block and sinus node dysfunction, leading to a clinically relevant prolongation of estimated device battery longevity.
Cite This Study
Stockburger et al. (2015) studied this question.