Key result
Immediate MCE defect size strongly predicts ultimate infarct size at longer pulsing intervals.
Why the study?
It was hypothesized that detecting regions with adequate collateral-derived myocardial blood flow within the risk area could predict ultimate infarct size at the time of acute coronary occlusion.
Does myocardial contrast echocardiography predict ultimate infarct size at the time of acute coronary occlusion in a canine model?
Comparison
Coronary occlusion without reperfusion (n=15) vs occlusion and reperfusion (n=6)
Design
Animal experimental study
Authors
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MCE detection of collateral MBF during occlusion may aid early IS prediction in acute coronary syndromes; leaves open translation to human reperfusion strategies.
Does myocardial contrast echocardiography predict ultimate infarct size at the time of acute coronary occlusion in a canine model?
Effect estimate: r>=0.92
Myocardial contrast echocardiography can accurately predict ultimate infarct size early after coronary occlusion by assessing collateral-derived myocardial blood flow.
Coggins et al. (2001) studied Acute coronary occlusion (n=21). Myocardial contrast echocardiography (MCE) was evaluated on Correlation between perfusion defect size on MCE and ultimate infarct size (r>=0.92). Myocardial contrast echocardiography immediately after coronary occlusion strongly correlated with ultimate infarct size at pulsing intervals >=10.6 seconds (r>=0.92).
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