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December 1, 1994Journal of Cardiovascular Pharmacology

Effect of Ranolazine on Infarct Size in a Canine Model of Regional Myocardial Ischemia/Reperfusion

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Why the study?

Does ranolazine reduce myocardial infarct size in a canine model of regional myocardial ischemia/reperfusion?

Population

Anesthetized dogs subjected to 90-min occlusion and 18-h reperfusion of the left circumflex coronary artery.

Comparison

Ranolazine administered as a bolus of 3.3 mg/kg… vs Appropriate volumes of vehicle.

Design

Preclinical

Follow-up

18 hours of reperfusion

Authors

SBShawn C. BlackBrigham and Women's HospitalMGMichael GralinskiAngioDynamics (United States)JMJames G. McCormackUniversity of Leeds

Discussion

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Implication

Ranolazine did not reduce infarct size in this canine model; leaves open its role in other ischemia/reperfusion contexts.

Structured PICO

Does ranolazine reduce myocardial infarct size in a canine model of regional myocardial ischemia/reperfusion?

P
Population
Anesthetized dogs subjected to 90-min occlusion and 18-h reperfusion of the left circumflex coronary artery (LCX) (n=27 total, 21 analyzed).
I
Intervention
Ranolazine administered as a bolus of 3.3 mg/kg, followed by a constant infusion of 7.2 mg/kg/h for 20 h, with the loading dose administered 30 min before LCX occlusion.
C
Comparator
Appropriate volumes of vehicle (loading and infusion).
O
Outcome
Myocardial infarct size (IS)surrogate

Ranolazine did not provide protection from injury to regionally ischemic and reperfused myocardium in a canine model.

Cite This Study

Black et al. (1994) studied this question.

synapsesocial.com/papers/6a740951acfb3e7ed3eafd74https://doi.org/10.1097/00005344-199424060-00009
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Ranolazine, an Inhibitor of the Late Sodium Channel Current, Reduces Postischemic Myocardial Dysfunction in the Rabbit2006 · 47 citations
  2. 2Ranolazine, an antianginal agent, markedly reduces ventricular arrhythmias induced by ischemia and ischemia-reperfusion2009 · 75 citations
  3. 3Cardioprotection by Ranolazine in Perfused Rat Heart2014 · 4 citations
  4. 4The Antianginal Agent Ranolazine is a Potent Antiarrhythmic Agent that Reduces Ventricular Arrhythmias: Through a Mechanism Favoring Inhibition of Late Sodium Channel2010 · 25 citations
  5. 5Electrophysiological Effects of Ranolazine, a Novel Antianginal Agent With Antiarrhythmic Properties2004 · 680 citations