What question did this study set out to answer?

To determine baseline incidence rates and secular trends of intussusception and rotavirus diarrhea, and to assess whether an excess of intussusception cases occurred during the first nine months of rotavirus vaccination.

July 1, 2001PEDIATRICS

Intussusception, Rotavirus Diarrhea, and Rotavirus Vaccine Use Among Children in New York State

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To determine baseline incidence rates and secular trends of intussusception and rotavirus diarrhea, and to assess whether an excess of intussusception cases occurred during the first nine months of rotavirus vaccination.
Reviewed New York State hospital discharge records from 1989 to 1998 for infants younger than 1 year diagnosed with intussusception or rotavirus diarrhea.
Audited hospital charts and vaccination records for a subset of 20 intussusception admissions between October 1998 and June 1999.
Estimated vaccine-attributable intussusception cases assuming 21% vaccine coverage and utilizing risk estimates from the National Immunization Program.
Identified 1,450 infant intussusception hospitalizations between 1989 and 1998 (average annual incidence of 5.4 per 10,000), with rates declining from 6.1 per 10,000 in 1989 to 3.9 per 10,000 in 1998.
Hospitalizations for intussusception occurred steadily throughout the year, whereas rotavirus admissions displayed pronounced seasonality peaking from February to April.
Observed 81 intussusception cases during the 9-month vaccination period compared with 78 during the prevaccination period, representing an observed excess of 3 cases versus 12 expected cases based on national risk estimates.

Authors

HCHwa‐Gan H. ChangAlbany Research Institute PSPerry F. SmithUniversity at Albany, State University of New York JAJoel AckelsbergCenters for Disease Control and Prevention

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Implication

Retrospective analysis reveals stable intussusception rates after rotavirus vaccine introduction in infants, suggesting minimal population-level excess risk.

Cite This Study

Chang et al. (2001) studied this question.

synapsesocial.com/papers/6a7413b07be5820ec40a4b67 https://doi.org/10.1542/peds.108.1.54

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Implication

Retrospective analysis reveals stable intussusception rates after rotavirus vaccine introduction in infants, suggesting minimal population-level excess risk.

Intussusception, Rotavirus Diarrhea, and Rotavirus Vaccine Use Among Children in New York State

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Discussion

Implication

Cite This Study

Intussusception, Rotavirus Diarrhea, and Rotavirus Vaccine Use Among Children in New York State

Key Points

Discussion

Implication

Cite This Study

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