What question did this study set out to answer?

This study aims to clarify the conditions under which end ejection coincides with end systole in the ventricle using simulation.

January 1, 1981Japanese Heart JournalOpen Access

Dissociation of end ejection from end systole of ventricle.

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Population

Simulated left ventricle model using time-varying elastance E and afterload with constant pressure…

Design

Preclinical

Authors

HSHiroyuki SugaShinshu University NNNaoki NishiuraKurashiki Central Hospital

Discussion

Member takes

Implication

Caution against equating end ejection with end systole for Emax assessment; simulation leaves open in vivo validation of afterload effects.

Key Points

This study aims to clarify the conditions under which end ejection coincides with end systole in the ventricle using simulation.
Simulated left ventricle with time-varying elastance, E(t).
E(t) follows a sinusoidal wave pattern during the cardiac cycle.
Computed ventricular pressure, volume, and flow using ordinary differential equations.
End ejection coincides with end systole when resistance (R) and inertance (L) values align on a specific curve in the R-L domain.
When R and L do not meet the criteria, end ejection and end systole vary independently.
End ejection should not be used as a stand-in for end systole in assessing pressure-volume relationships.

Structured PICO

Population

Simulated left ventricle model using time-varying elastance E(t) and afterload with constant pressure, resistance R, and inertance L

Intervention

Simulation of varying system parameters (resistance R and inertance L)

Outcome

Coincidence of end ejection and end systolesurrogate

End ejection should not be used as a substitute for end systole when assessing Emax and end-systolic pressure-volume relations due to their variable dissociation based on afterload.

Cite This Study

Suga et al. (1981) studied this question.

synapsesocial.com/papers/6a7419775e45dc7750a8d2c1 https://doi.org/10.1536/ihj.22.117

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Implication

Caution against equating end ejection with end systole for Emax assessment; simulation leaves open in vivo validation of afterload effects.

Dissociation of end ejection from end systole of ventricle.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Dissociation of end ejection from end systole of ventricle.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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