Why the study?
Does simvastatin or pravastatin improve cognitive function in patients with hypercholesterolaemia?
Does simvastatin or pravastatin improve cognitive function in patients with hypercholesterolaemia?
Short-term treatment with simvastatin or pravastatin does not significantly affect cognitive function in patients with hypercholesterolaemia compared to placebo.
No short-term cognitive benefit from simvastatin or pravastatin; confirms null acute effects and leaves longer-term impacts open.
The effects of equi-efficacious doses of the cholesterol-lowering drugs simvastatin (20 mg day-1) and pravastatin (40 mg day-1) on tests of cognitive function were investigated in a double-blind, placebo-controlled, 2-period (4 weeks per period), incomplete block, crossover study of 36 patients (24 per treatment) with hypercholesterolaemia. After 4 weeks neither of the active treatments differed significantly from placebo on any cognitive measure.
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Cutler et al. (1995) studied this question.
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