Key result
Simvastatin and atorvastatin significantly improved cognitive function in obese hypertensive patients after 12 months of therapy.
Why the study?
Does simvastatin compared to atorvastatin improve cognitive function in obese hypertensive patients?
RCT (n=40)
Open-label
Does simvastatin compared to atorvastatin improve cognitive function in obese hypertensive patients?
Both simvastatin and atorvastatin monotherapy for 12 months significantly improve cognitive function in obese hypertensive patients.
May support cognitive benefits of statins in obese hypertension; leaves open which agent is preferable.
Objective. To assess the influence of simvastatin vs. atorvastatin therapy on cognitive function in obese hypertensive patients. Design and methods. This open clinical trial included 40 patients (mean age 47,7 ± 5,6 years). 20 patients received simvastatin and 20 — atorvastatin. Monotherapy lasted 12 months. At baseline and 12 months later, all participants underwent neuropsychological testing and cognitive evoked potential (P300) to assess cognitive function. Results. 12-month therapy with simvastatin and atorvastatin significantly improved cognitive function (neuropsychological testing and P300) in obese hypertensives.
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Зуева et al. (2012) conducted an RCT in Obese hypertension (n=40). Simvastatin vs. Atorvastatin was evaluated on Cognitive function (neuropsychological testing and P300). Simvastatin and atorvastatin significantly improved cognitive function in obese hypertensive patients after 12 months of therapy.
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