ACCORD‐ADEQUATE: an improved technique for the acquisition of inverse‐detected INADEQUATE data

A new approach for the acquisition of 1 H‐detected INADEQUATE‐type data is presented. This method uses a decremented variable delay for the evolution of 1 J (C,C) couplings. It is demonstrated that this variation of the 1,1‐ADEQUATE experiment provides superior performance when compared with the normal static‐optimized 1,1‐ADEQUATE experiment. This improvement is manifested in both the number and quality of correlations present in the processed data. The technique was validated using the model compound ethyl trans ‐crotonate and its utility was demonstrated utilizing the structurally unique marine natural product jamaicamide A.