What question did this study set out to answer?

To evaluate the association between office blood pressure versus 24-hour ambulatory blood pressure and left ventricular structure and function, and to determine whether these associations differ by sex.

May 1, 2022International Journal of General MedicineOpen Access

Association of Office and Ambulatory Blood Pressure with Left Ventricular Structure and Function in Hypertensive Patients

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Why the study?

To evaluate the association of office blood pressure and 24h ambulatory blood pressure with left ventricular structure and function in hypertensive patients, and determine whether sex modifies this association.

Does 24h ambulatory blood pressure associate more strongly with left ventricular structural and functional alterations than office blood pressure in hypertensive patients?

Population

694 hypertensive patients without cardiovascular disease from an inpatient clinic

Comparison

OBP vs 24h ABP parameters, stratified by sex

Design

Retrospective cross-sectional study

Authors

ZSZhuo SangSun Yat-sen University XZXianli ZengChina University of Geosciences YXYuan XiaohuiEast China University of Science and Technology

Discussion

Member takes

Implication

24h ABP may link more closely to LV changes than OBP in hypertension; leaves open sex-specific monitoring value pending prospective data.

Key Points

To evaluate the association between office blood pressure versus 24-hour ambulatory blood pressure and left ventricular structure and function, and to determine whether these associations differ by sex.
Retrospectively analyzed N=694 hypertensive patients without cardiovascular disease from an inpatient clinic.
Performed regression analyses assessing office and 24-hour ambulatory blood pressure parameters against left ventricular mass index (LVMi), e' velocity, and left ventricular hypertrophy (LVH), adjusting for age, obesity, diabetes, sleep apnea, renal function, and antihypertensive medications.
Men had significantly higher 24-hour (132.6 ± 11.3 vs 129.3 ± 10.0 mm Hg), daytime (136.6 ± 12.9 vs 132.8 ± 9.5 mm Hg), and nighttime (130.3 ± 9.2 vs 125.1 ± 6.6 mm Hg) systolic blood pressure compared to women, alongside higher rates of non-dipping and reverse dipper patterns.
In the overall cohort, 24-hour, daytime, and nighttime systolic blood pressure, as well as non-dipping and reverse dipper patterns, were significantly associated with LVMi, e' velocity, and LVH, whereas office blood pressure showed no such associations.
The associations between ambulatory blood pressure metrics and left ventricular structural and functional alterations were significantly stronger in men than in women (P for interaction < 0.05).

Structured PICO

Does 24h ambulatory blood pressure associate more strongly with left ventricular structural and functional alterations than office blood pressure in hypertensive patients?

Population

694 hypertensive patients without cardiovascular disease retrospectively included from an inpatient clinic.

Intervention

24h ambulatory blood pressure (ABP) monitoring

Comparator

Office blood pressure (OBP) measurement

Outcome

Left ventricular mass index (LVMi), e' velocity, and left ventricular hypertrophy (LVH)surrogate

24-hour ambulatory blood pressure is superior to office blood pressure in correlating with left ventricular structural and functional alterations in hypertensive patients, with a stronger association observed in men.

Cite This Study

Sang et al. (2022) studied this question.

synapsesocial.com/papers/6a742709c142ebe13133f89c https://doi.org/10.2147/ijgm.s357508

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Association of Office and Ambulatory Blood Pressure with Left Ventricular Structure and Function in Hypertensive Patients

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Association of Office and Ambulatory Blood Pressure with Left Ventricular Structure and Function in Hypertensive Patients

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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