What question did this study set out to answer?

To investigate the biological composition of left ventricular hypertrophy by separating myocardial mass into cellular and extracellular matrix components using cardiovascular magnetic resonance T1 mapping.

December 19, 2017CirculationOpen Access

Left Ventricular Hypertrophy Revisited

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Why the study?

Does CMR with T1 mapping and ECV measurement differentiate cellular and matrix components across different causes of left ventricular hypertrophy?

Key Points

To investigate the biological composition of left ventricular hypertrophy by separating myocardial mass into cellular and extracellular matrix components using cardiovascular magnetic resonance T1 mapping.
Evaluated 190 total participants using cardiovascular magnetic resonance, comprising healthy volunteers (n=30) and subjects with left ventricular hypertrophy (n=160).
Included five distinct hypertrophy cohorts: athletes (n=50), severe aortic stenosis awaiting valve replacement (n=30), Fabry disease (n=20), hypertrophic cardiomyopathy (n=30), and cardiac amyloidosis (n=30).
Calculated extracellular volume fraction (ECV) via T1 mapping to partition total left ventricular mass into indexed cellular and extracellular matrix volumes.
Most etiologies of left ventricular hypertrophy demonstrated a balanced, proportional expansion of both cellular and extracellular matrix compartments.
Athletic remodeling exhibited predominantly cellular hypertrophy with minimal matrix expansion, whereas cardiac amyloidosis demonstrated almost exclusively extracellular matrix expansion.

Structured PICO

Does CMR with T1 mapping and ECV measurement differentiate cellular and matrix components across different causes of left ventricular hypertrophy?

Population

190 subjects, including healthy volunteers (n=30) and 160 subjects with left ventricular hypertrophy (LVH) defined as increased indexed LVM: athletes (n=50), severe aortic stenosis awaiting valve replacement (n=30), Fabry disease (n=20), hypertrophic cardiomyopathy (n=30), and cardiac amyloidosis (n=30).

Intervention

Cardiovascular magnetic resonance (CMR) using T1 mapping to measure extracellular volume fraction (ECV)

Comparator

Comparison across different LVH etiologies and healthy volunteers

Outcome

Cellular and matrix components of left ventricular mass (LVM)surrogate

CMR T1 mapping with ECV can differentiate the underlying cellular versus extracellular matrix expansion in various forms of left ventricular hypertrophy, providing pathophysiological insights beyond simple mass quantification.

Discussion

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Implication

Differentiates cellular versus matrix LVH by etiology; leaves open whether ECV phenotyping guides therapy.

Cite This Study

Treibel et al. (2017) studied this question.

synapsesocial.com/papers/6a74270dc142ebe13133f8b1 https://doi.org/10.1161/circulationaha.117.029895

View Full Paper

Ask AI

Bookmark

Left Ventricular Hypertrophy Revisited

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Left Ventricular Hypertrophy Revisited

Key Points

Structured PICO

Discussion

Implication

Cite This Study

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