June 1, 2001Cardiovascular ResearchOpen Access

Increased basal contractility of cardiomyocytes overexpressing protein kinase Cε and blunted positive inotropic response to endothelin-1

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Population

Cultured adult rabbit ventricular myocytes

Comparison

Adenovirus-mediated gene transfer to… vs Ad-LacZ control transfected cells

Design

Preclinical

Authors

SBS. BaudetUniversité Paris-Sud

Discussion

Member takes

Implication

PKCε overexpression may boost basal myocyte contractility in rabbits; hypothesis-generating for human inotropic therapies, pending clinical validation.

Structured PICO

Population

Cultured adult rabbit ventricular myocytes

Intervention

Adenovirus-mediated gene transfer to specifically overexpress PKC epsilon (Ad-PKC epsilon)

Comparator

Ad-LacZ control transfected cells

Outcome

Myocyte shortening and [Ca2+]i transients under basal and ET-1-stimulated conditionssurrogate

Specific overexpression of PKC epsilon in rabbit ventricular myocytes increases basal contractility and calcium transients while blunting the positive inotropic response to endothelin-1.

Cite This Study

S. Baudet (2001) studied this question.

synapsesocial.com/papers/6a7428cd3044697dfb6e8735 https://doi.org/10.1016/s0008-6363(01)00225-5

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Implication

PKCε overexpression may boost basal myocyte contractility in rabbits; hypothesis-generating for human inotropic therapies, pending clinical validation.

Increased basal contractility of cardiomyocytes overexpressing protein kinase Cε and blunted positive inotropic response to endothelin-1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Increased basal contractility of cardiomyocytes overexpressing protein kinase Cε and blunted positive inotropic response to endothelin-1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider