Why the study?
Pathophysiologic investigations into Takotsubo cardiomyopathy have progressed slowly and with inadequate focus over 30 years, leaving its complex and dynamic manifestations incompletely explained by catecholamine effects alone.
Design
Review and clinical perspective
Authors
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Coronary spasm may initiate TTC modulated by CAD; leaves open prospective validation of ACh testing before clinical adoption.
This review challenges the dominant catecholamine surge theory of Takotsubo cardiomyopathy, proposing instead that coronary spasm modulated by atherosclerosis is the primary pathophysiologic mechanism.
Angelini et al. (2021) studied this question.
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