January 31, 2013Current BiologyOpen Access

Vinculin Regulates the Recruitment and Release of Core Focal Adhesion Proteins in a Force-Dependent Manner

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Population

Cell models

Design

Preclinical

Authors

ACAlexandre F. CariseySt. Jude Children's Research Hospital RTRicky TsangUniversity of British Columbia AGAlexandra M. GreinerKarlsruhe Institute of Technology

Discussion

Member takes

Implication

No immediate clinical implications in cardiology; hypothesis-generating for vinculin-mediated mechanosensing in stretched cells.

Structured PICO

Population

Cell models

Intervention

Vinculin mutants and cyclic stretching

Outcome

Recruitment and release of core focal adhesion components and reorganization of cell polarity

Vinculin controls the transmission of intracellular and extracellular mechanical cues essential for focal adhesion dynamics and polarized cell motility.

Cite This Study

Carisey et al. (2013) studied this question.

synapsesocial.com/papers/6a7436ec17dd9a89f6092b65 https://doi.org/10.1016/j.cub.2013.01.009

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Vinculin Regulates the Recruitment and Release of Core Focal Adhesion Proteins in a Force-Dependent Manner

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Vinculin Regulates the Recruitment and Release of Core Focal Adhesion Proteins in a Force-Dependent Manner

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider