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August 6, 2026Therapeutic Delivery

Engineering strategies and translational progress in targeted nanoparticle drug delivery

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Authors

NANithya AjayChettinad Academy of Research and EducationAAAnu Shibi AnilkumarChettinad Academy of Research and EducationRVRamakrishnan VeerabathiranChettinad Academy of Research and Education

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Implication

Review evaluates nanoparticle strategies for drug delivery, highlighting targeting methods and barriers to translation.

Key Points

  • This review aims to explore engineering strategies for nanoparticle drug delivery and discuss translational challenges.
  • Comprehensive examination of nanoparticle carrier types including lipid-based, polymeric, inorganic, and hybrid systems.
  • Discussion of targeting methods: passive targeting via EPR effect and active targeting using ligands like antibodies and peptides.
  • Analysis of biological barriers impacting clinical translation, including tumor heterogeneity and immune clearance.
  • Identified significant advancements in structural design and drug release mechanisms of nanocarriers.
  • Highlighted emergence of stimuli-responsive systems for controlled drug release based on environmental triggers.
  • Noted ongoing challenges in clinical translation due to biological complexities and scaling.

Cite This Study

Ajay et al. (2026) studied this question.

synapsesocial.com/papers/6a743730764cddc9499d46d8https://doi.org/10.1080/20415990.2026.2713917
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