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August 6, 2026Journal of Ovarian ResearchOpen Access

Research progress on multi-mechanism analysis and protection strategies of ovarian aging and fertility decline

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Authors

JCJianhui ChenXDXiaohui DuanYJYaling Jing

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Overview

Review examines mechanisms of ovarian aging and proposes strategies for fertility preservation in aging women, suggesting integrated approaches.

Key Points

  • This review explores the interconnected mechanisms of ovarian aging and their impact on fertility. It also proposes strategies to address age-related fertility decline.
  • Proposes an ovary-centered, multi-mechanistic framework to integrate existing evidence on ovarian aging.
  • Discusses roles of various stress and signaling pathways related to follicle depletion and oocyte competence.
  • Evaluates mechanism-oriented intervention strategies for fertility preservation.
  • Identifies key factors like genomic instability, mitochondrial dysfunction, and oxidative stress in ovarian aging.
  • Highlights specific signaling pathways that contribute to follicle activation and stress adaptation.
  • Suggests comprehensive intervention strategies could improve reproductive health in aging populations.

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/6a74374b764cddc9499d47eehttps://doi.org/10.1186/s13048-026-02203-w
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