Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 6, 2026Journal of Clinical Psychopharmacology

Olanzapine/Samidorphan-Associated Opioid Withdrawal Reported to US Poison Centers

View Full Paper
Ask AI
Bookmark
Share

Authors

JLJames B. LeonardSMSheila Mohebbi

Discussion

Loading...

Member takes

Overview

Retrospective evaluation reports opioid withdrawal in patients using olanzapine/samidorphan, suggesting a need for careful screening.

Key Points

  • This research aims to evaluate cases of opioid withdrawal linked to the use of olanzapine/samidorphan reported to poison centers.
  • Retrospective evaluation of olanzapine/samidorphan cases reported to the National Poison Data System from May 1, 2021, to June 30, 2025.
  • Reviewed coded data to identify patients experiencing opioid withdrawal and extracted clinical factors from case notes.
  • 426 cases were reported, with 31 involving opioid withdrawal.
  • Opioid withdrawal lasted about 24 hours for most patients, with seven requiring intubation for management.

Cite This Study

Leonard et al. (2026) studied this question.

synapsesocial.com/papers/6a74379d764cddc9499d4fcahttps://doi.org/10.1097/jcp.0000000000002244
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Treating Schizophrenia and Bipolar I Disorder in the Real-World Setting2024 · 1 citations
  2. 2Combination of olanzapine and samidorphan has no clinically relevant effects on ECG parameters, including the QTc interval: Results from a phase 1 QT/QTc study2020 · 14 citations
  3. 3Disproportionality evaluation of risk signals of a novel antischizophrinic olanzapine/samidorphan: a pharmacoepidemiology study via FAERS2024
  4. 4Zolpidem dependence with delayed-onset opioid-like withdrawal symptoms2024 · 1 citations
  5. 5Exploring Olanzapine Overdose in an Ethiopian Patient: A Case Report2025