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This research investigates how recipient endothelial cells influence acute graft-versus-host disease pathology via IRF1 signaling.

August 6, 2026Blood

Recipient Endothelial IRF1 mediates IFNγ-driven tissue tolerance in mouse models of acute Graft-versus-Host Disease.

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This research investigates how recipient endothelial cells influence acute graft-versus-host disease pathology via IRF1 signaling.
Single cell RNA-sequencing of endothelial cells from the liver
In vivo experiments with IFNγ neutralization and JAK inhibition in mouse models
Co-cultures of lymphatic endothelial cells and CD4 T cells
IRF1+ MHC II+ PD-L1+ lymphatic endothelial cells increased after allo-HCT (P<0.05)
IFNγ blockade impaired Treg expansion, leading to worsened GVHD severity
JAK inhibition reduced pathogenic Th1 cells and improved survival in transplant models (P<0.01)

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Randomized trial uncovers the role of endothelial IRF1 in tissue tolerance during acute graft-versus-host disease, suggesting therapeutic targets.

Neidemire-Colley et al. (2026) studied this question.

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Randomized trial uncovers the role of endothelial IRF1 in tissue tolerance during acute graft-versus-host disease, suggesting therapeutic targets.