What question did this study set out to answer?

To explore how reduced sensory inputs from modern lifestyles may lead to interoceptive dysregulation and related anxiety disorders.

August 6, 2026CureusOpen Access

Embodied Sensory Deprivation Hypothesis (ESDH): An Evolutionary Model of Sensory Malnutrition Linking Interoceptive Dysregulation, Anxiety, and Disorders of Gut-Brain Interaction

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Proposed hypothesis links sensory malnutrition to anxiety and gut-brain disorders, suggesting new treatment avenues.

To explore how reduced sensory inputs from modern lifestyles may lead to interoceptive dysregulation and related anxiety disorders.
Proposed a theoretical framework summarizing evolutionary and neurophysiological concepts.
Reviewed models of predictive coding and allostasis to understand sensory integration in the nervous system.
Proposed sensory malnutrition may contribute to anxiety-related conditions and Disorders of Gut-Brain Interaction.
Identified potential for a new clinical syndrome based on the emerging profile of interoceptive dysregulation.

Bertuccioli et al. (2026) studied this question.

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