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August 6, 2026Organic Letters

Ruthenium-CatalyzedC–H Alkenylation of Phosphines:Reaction Development, Mechanistic Studies, and Applications to LigandDesign

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Authors

LWLiang‐Neng WangXCXiaohong ChenDCDongbo Cai

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Overview

Randomized trial reveals efficient synthesis of olefin-phosphines in ligand design, suggesting broad applications in catalysis.

Key Points

  • This research aims to develop a robust method for the C–H alkenylation of phosphines, contributing to ligand design.
  • Ruthenium-catalyzed C–H olefination of tertiary phosphines using alkenyl reagents
  • Synthesis of a library of 55 olefin-phosphines
  • Mechanistic studies supported by DFT calculations.
  • High yields for olefin-phosphines with ≥15 different functional groups
  • Catalyst loadings as low as 0.005 mol % in Suzuki coupling
  • Superior performance compared to commercial biarylphosphines in Pd-catalyzed reactions.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a7437ba764cddc9499d556dhttps://doi.org/10.1021/acs.orglett.6c01996
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