Key result
Adolescent type 1 diabetes is linked to lower very-low and low-frequency HRV versus healthy controls.
Why the study?
The study aimed to compare heart rate variability between adolescents with type 1 diabetes and healthy controls, and to investigate how heart rate variability may change during puberty.
Does type 1 diabetes reduce heart rate variability in adolescents compared to healthy controls?
Comparison
Adolescents with type 1 diabetes vs healthy age- and sex-matched control participants
Design
Cross-sectional study
Authors
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HRV alterations may occur in T1D adolescents; leaves open pubertal effects and clinical relevance pending longitudinal data.
Cross-Sectional (n=188)
No
Does type 1 diabetes reduce heart rate variability in adolescents compared to healthy controls?
Absolute Event Rate: 7.94% vs 8.14%
p-value: p=0.005
Adolescents with type 1 diabetes exhibit depressed heart rate variability in low and very low frequencies compared to healthy controls, suggesting early autonomic nervous system dysfunction associated with metabolic factors.
Koivikko et al. (2026) conducted a cross-sectional in Type 1 diabetes (n=188). Type 1 diabetes vs. Healthy age- and sex-matched controls was evaluated on Very low frequency (VLF) domain of heart rate variability (ln ms2) (p=0.005). Adolescents with type 1 diabetes exhibited significantly lower very low frequency (7.94 vs 8.14 ln ms2, P=0.005) and low frequency (P=0.049) heart rate variability compared to healthy controls.
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