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A practical synthesis of 5‐(chloromethyl)furo[2,3‐ b ]pyridine ( 10 ), the side chain used to incorporate a key pharmacophore of the HIV protease inhibitor, L‐754,394, is described. The synthesis was accomplished in ten steps and in 15% overall yield from commercially available methyl 2‐furoate.
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Bhupathy et al. (1995) studied this question.
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