Liposomes from α,ω‐dipolar amphiphiles with a polymerizable diyne moiety in the hydrophobic chain

Symmetric polymerizable α,ω‐dipolar C 22 ‐diacetylenes were prepared by oxidative coupling of 10‐undecynoic acid and 10‐undecynol, respectively, by means of copper II salts in ethanolic solution. 10,12‐Docosadiyne‐1,22‐diphosphate ( 3 )—by reaction of 10,12‐docosadiyne‐1,22‐diol ( 2 ) with POCl 3 —was polymerized in aqueous solution using UV irradiation to form deep blue, thermochromic solutions. By consonication of 3 with cholesterol, monolayer vesicles were formed. This was proven by encapsulation of 6‐carboxyfluorescein. These monomeric vesicles were polymerized by UV light to yield stable, deep blue polymeric vesicle suspensions.