Effect of Renal Transplantation on Cardiovascular Risk Factors in Patients with Chronic Kidney Disease

Cardiovascular disease is a common cause of morbidity and mortality in patients with chronic kidney disease (CKD), before and after a kidney transplantation (KT). The aim of this study was to evaluate the effect of KT on cardiovascular diseases (CVD) risk factors – lipid profile, HDL-associated antioxidative enzyme paraoxonase (PON), neopterin (Neo), high-sensitivity C-reactive protein (CRP), and thromboxanes (TBX) - some of which reflecting proinflammatory state of recipients as well as effect of asymmetric dimethylarginine (ADMA), a new independent cardiovascular risk factor. 63 patients with CKD and 49 patients after a KT were included into the study. Kidney transplant patients had good graft function (MDRD = 1.078 ml/s per 1.73 m2, serum creatinine levels 99.18 mmol/l). Total, HDL-, LDL-cholesterols were increased but in physiological range. Arylesterase resp. lactonase activities of PON A were increased by 23,9 % and 37,3 % resp. in KT patients in comparison to CKD patients. The level of Neo, CRP, TBX and ADMA were significantly decreased (by 90.28%; 48.17%; 57.07% and 16.08% resp.) after KT. Our data allow us to conclude that transplantation decreases in patients possible cardiovascular risk.