Influence of permeating ions on Kv1.5 channel block by nifedipine
Population
Kv1.5 channels (wild-type and mutants W472F, R487V, R487Y)
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Should not change nifedipine use; hypothesis-generating for permeant-ion effects on Kv1.5 block.
Structured PICO
P
Population
Kv1.5 channels (wild-type and mutants W472F, R487V, R487Y)
I
Intervention
Nifedipine block under varying intra- and extracellular permeating ions (K+, Rb+, Cs+)
O
Outcome
Potency of nifedipine block (IC50) and voltage dependencesurrogate
Nifedipine block of Kv1.5 channels is conditioned by the permeating ion and outer pore conformation, coexisting with but distinct from C-type inactivation.
Cite This Study
Lin et al. (2001) studied this question.