November 1, 1999AJP Heart and Circulatory Physiology
Sequential gating in the human heart K+channel Kv1.5 incorporatesQ1andQ2charge components
Population
Kv1.5 cardiac delayed rectifier K(+) channel expressed in HEK-293 cells
Design
Preclinical
Authors
Discussion
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Member takes
Implication
Supports five-state Kv1.5 gating model; extends channel-block insights in animal data but leaves open human translation.
Structured PICO
P
Population
Kv1.5 cardiac delayed rectifier K(+) channel expressed in HEK-293 cells
I
Intervention
Voltage depolarizations and 4-aminopyridine (1 mM)
O
Outcome
Separation and characterization of on-gating current into Q1 and Q2 charge systemssurrogate
The identification of Q1 and Q2 charge systems in the Kv1.5 channel allows for a five-state model of gating, aiding in the understanding of cardiac K+ channel block mechanisms.
Cite This Study
Hesketh et al. (1999) studied this question.