Key result
The Kv1.2 potassium channel gating charge is near 10 elementary charges, approximately 25% less than the 13-14 elementary charges observed in Shaker channels.
The voltage-sensing domains of Kv1.2 and Shaker channels exhibit fundamental differences in gating charge and voltage sensitivity, suggesting structural differences such as a thicker septum in Kv1.2.
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Questions extrapolation from Shaker models to Kv1.2; leaves open relevance to human cardiac excitability.
Ishida et al. (2015) studied Kv1.2 potassium channel gating. Kv1.2 S4 transmembrane segment mutagenesis vs. Wild-type Kv1.2 and Shaker channels was evaluated on Gating charge (elementary charges, e_o). The Kv1.2 potassium channel gating charge is near 10 elementary charges, approximately 25% less than the 13-14 elementary charges observed in Shaker channels.
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