Population
Mammalian Shaker family potassium ion (K+) channel Kv1.2
Design
Preclinical
Authors
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May inform Kv channel modulator design for arrhythmias; extends structural models but leaves open human translation.
The crystal structure of the Kv1.2 channel reveals how voltage sensors operate as independent domains to mechanically open and close the channel pore.
Long et al. (2005) studied this question.
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