Population
360 Kv channel sequences for statistical coupling analysis, and Shaker/KvAP channels expressed in Xenopus…
Comparison
Mutagenesis and disulfide cross-linking of the… vs Wild-type channels or reduced state channels
Design
Preclinical
Authors
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No immediate clinical implications; leaves open the S1-pore interface as a potential target for Kv channel modulation in disease.
Identification of a second critical interface between the voltage sensor and pore provides new mechanistic insights into how voltage-dependent K+ channels regulate gating.
Lee et al. (2009) studied this question.
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