Population
KV10.1 channels (in vitro model)
Comparison
Expression of voltage-sensing domain and pore… vs Intact KV10.1 channels
Design
Preclinical
Authors
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Challenges S4–S5 linker model in KCNH channels; leaves open alternative VSD-PD coupling for further study.
The study provides evidence that the inward motion of the C-terminal S4 helix, rather than the S4-S5 linker, closes the KV10.1 channel gate, suggesting multiple mechanisms control the pore.
Tomczak et al. (2017) studied this question.
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