The pharmacological activity and fluorescence characteristics of extracts of an appendiceal carcinoid tumor could be accounted for entirely by its serotonin content. The amount of serotonin in the carcinoid tissue was about 1000 times that of normal tissue, and its enzymatic ability to form serotonin from 5-hydroxytryptophane was about 35 times that of normal human appendiceal tissue.
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Giarman et al. (1957) studied this question.