Why the study?
Does intra-arterial amitriptyline increase forearm blood flow in healthy subjects?
Does intra-arterial amitriptyline increase forearm blood flow in healthy subjects?
Intra-arterial amitriptyline induces local vasodilation in resistance vessels, likely mediated by alpha-adrenergic blockade, without systemic hemodynamic effects.
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May indicate local vasodilation by intra-arterial amitriptyline in healthy subjects; leaves open therapeutic relevance in vascular disease.
The local effect of intra-arterial infusion of amitriptyline (AT) on forearm blood flow was studied in seven healthy subjects. AT was infused at rates of 0.05, 0.10, 0.15, and 0.20 mg-min--1 for periods of 5 min. Forearm blood flow showed a dose-dependent increase when the dose exeeded 0.10 mg-min--1. On the highest dose level the blood flow increased on an average by 73%. No systemic effects, as reflected by changes in heart rate, blood pressure, and blood flow in the contralateral forearm, were observed during the infusion. The present data indicate a dilatating effect of AT on resistance vessels possibly mediated by an alpha-adrenergic blockade.
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Thorstrand et al. (1976) studied this question.
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