Why the study?
It was unknown whether elevated baseline blood flow induced by intra-arterial adenosine or ATP affects the rapid-onset vasodilatory response to a single muscle contraction.
Does elevated baseline blood flow induced by adenosine or ATP alter the rapid-onset vasodilatory response to a single muscle contraction in healthy young participants?
Population
24 healthy young participants (28 ± 1 years)
Comparison
Intra-arterial infusion of ADO vs ATP vs saline control
Authors
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Supports feedforward vasodilation during contraction; leaves open relevance in cardiovascular disease.
Does elevated baseline blood flow induced by adenosine or ATP alter the rapid-onset vasodilatory response to a single muscle contraction in healthy young participants?
Augmented baseline blood flow does not affect the peak vasodilatory response to a single muscle contraction, suggesting the response is driven by a feedforward vasodilatory mechanism.
Dillon et al. (2019) studied this question.