Human Urinary kallidinogenase promotes good recovery in ischemic stroke patients with level 3 hypertension

Aim To evaluate the clinical efficacy of Human Urinary kallidinogenase ( HUK ) in the treatment of acute ischemic stroke ( AIS ) patients with level 3 hypertension. Methods In this retrospective study, from January 2015 to June 2016, 150 consecutive AIS patients were registered in our database. Among them, 47 with level 3 hypertension received either HUK treatment ( HUK group, 22 cases) or basic treatment (control group, 25 cases). Basic treatment was administrated on all patients. 0.15 PNA unit of HUK injection plus 100 ml saline in intravenous infusion was performed in the HUK group, with once a day for 14 consecutive days. The modified Rankin Scale ( mRS ) scores in two groups were analyzed 3 months after the treatment. Results No difference was found in the NIHSS scores, age, gender, and comorbidities between two groups before treatment ( p > .05). While after treatment, 3‐month mRS score was significantly lower in the HUK group (2.1 ± 1.4 vs. 3.1 ± 1.3, p = .012) and good recovery rate (3‐month mRS score ≤2) in the HUK group was significantly higher than that in the control group ( p < .05). Conclusion HUK is able to promote long‐term recovery for AIS patients with level 3 hypertension remarkably.