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March 28, 2007International Journal of Gynecology & Obstetrics

Genital tuberculosis in Indian infertility patients

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Authors

NGNupur GuptaAllegheny Health NetworkJSJai Bhagwan SharmaAll India Institute of Medical SciencesSMS. MittalMahatma Gandhi Institute of Medical Sciences

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Implication

Prospective clinical study demonstrates extensive tubal damage and pelvic adhesions in infertile women with genital tuberculosis, highlighting the need for multimodal laparoscopic diagnosis.

Key Points

  • To evaluate the clinical presentations, diagnostic laparoscopy findings, and laboratory biopsy results in infertile women suspected of having genital tuberculosis.
  • Prospective clinical study conducted from October 2004 to August 2006 at a tertiary care hospital in India evaluating 150 women with clinically suspected genital tuberculosis.
  • Patients underwent diagnostic laparoscopy, endometrial aspiration, histopathological biopsy, acid-fast bacillus (AFB) culture, and polymerase chain reaction (PCR) assays after excluding other infertility etiologies.
  • Genital tuberculosis was confirmed in 40 women, presenting primarily with primary infertility (n=30) or secondary infertility (n=10), alongside menstrual abnormalities such as menorrhagia (n=9), hypomenorrhea (n=8), and amenorrhea (n=4).
  • Laparoscopy identified peritubal and periovarian adhesions (n=18), omental adhesions (n=18), Fitz-Hugh-Curtis syndrome (n=15), bowel adhesions (n=15), and tortuous, blocked fallopian tubes (n=13).
  • Diagnostic laboratory confirmation yielded positive PCR results in 9 patients, positive endometrial histology in 10 patients, positive Mantoux reactions in 2 patients, and positive AFB culture in 1 patient.

Cite This Study

Gupta et al. (2007) studied this question.

synapsesocial.com/papers/6a744d03b06f632524092f51https://doi.org/10.1016/j.ijgo.2006.12.018
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1FEMALE GENITAL TUBERCULOSIS1976 · 212 citations
  2. 2Tuberculous endometritis: a clinicopathological study of 1000 cases1983 · 53 citations