Recognition and Regulation by Modified Self

The starting point for much of the work to be discussed in this meeting, and especially for our work, is the fact that the immune system does not overtly respond to its own self antigens.It will become quite clear that this process of "self tolerance" is an active one.It has been our hypothesis during the course of our work over the last decade that foreign antigens associated with self antigens would therefore be nonimmunogenic; indeed, that they would be tolerogenic.A corollary to this hypothesis is that the major guideposts for