Chronic succinate exposure does not cause liver injury

Succinate has been associated with hepatotoxicity in cellular, animal, and human models, including metabolic syndrome. This is the first report that evaluates the liver integrity effect of chronically elevated systemic succinate as measured by mass spectrometry. We show that liver histopathology, functional readouts, and high-resolution respirometry show normal levels following chronic succinate exposure. Thus, this research challenges the prevalent concept that succinate elevation is injurious to the liver in vivo.