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SUMMARY.— The application of a topical anticholinergic agent (poldine methyl ‐methosulphate) to the forehead skin of 10 patients with mild acne vulgaris twice daily for 4 weeks produced a small but significant reduction in sebum excretion. This is compatible with the suggestion that the control of sebum secretion may have a cholinergic component, but the effect is small.
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CARTLIDGE et al. (1972) studied this question.
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