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ONE OF THE striking characteristics of functioning tumors of the adrenal cortex is the variety and variability of the clinical pictures which they produce. Even a cursory review of the reported cases and a glance at the photographs which usually accompany the case reports are sufficient to satisfy anyone who is skeptical regarding the truth of this statement. Such a review shows not only that the often described classical clinical pictures are different among boys, girls, men and women, but that grossly similar tumors produce widely different clinical effects even among members of the same sex and age groups. In some instances only one or two striking endocrine abnormalities will be present, to the relative or absolute exclusion of others. Some patients will be extremely weak; others unnaturally vigorous. Some will have striae, or hypertension, or diabetes or polycythemia, or all of these; others will not. Some cases present in all details the syndrome described by Cushing; in others the appearance of the patient will be totally different.
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Engstrom et al. (1944) studied this question.
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