Key result
Long-term clopidogrel therapy caused leucocytoclastic vasculitis in a 57-year-old woman, which resolved completely within 2 weeks of drug withdrawal.
Case Report (n=1)
Leucocytoclastic vasculitis is a rare but possible late adverse effect of long-term clopidogrel therapy that resolves upon drug withdrawal.
Clopidogrel may rarely cause late-onset leucocytoclastic vasculitis resolving on withdrawal; this case report is hypothesis-generating and should not change practice.
We describe a case of leucocytoclastic vasculitis manifested as exanthematous rash in a 57-year-old woman on long-term therapy with clopidogrel. The diagnosis was confirmed by skin biopsy. The patient was managed symptomatically with oral antihistaminics and topical steroids in consultation with dermatologists. Clopidogrel therapy was discontinued on suspicion of drug-induced vasculitis. The rash resolved completely within 2 weeks of withdrawal of clopidogrel, satisfying criteria for a probable adverse drug reaction. Leucocytoclastic vasculitis is an unusual adverse effect of clopidogrel therapy and even rarer as a late complication.
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Shetty et al. (2013) conducted a case report in Leucocytoclastic vasculitis (n=1). Clopidogrel was evaluated on Development and resolution of leucocytoclastic vasculitis. Long-term clopidogrel therapy caused leucocytoclastic vasculitis in a 57-year-old woman, which resolved completely within 2 weeks of drug withdrawal.
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