Remitting Seronegative Symmetrical Synovitis With Pitting Edema (Rs3pe) in a 75-Year-Old Woman: A Case Report

Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) is a rare inflammatory condition seen in elderly people. The disease is a syndrome characterized by sudden-onset swelling and pitting edema, holding hands and feet, especially in the distal extremities. RS3PE may be an alone disease or associated with malignancy, inflammatory rheumatic diseases or infections. The pathophysiology is not very clear. Its prevalence is not well known. Due to the presence in the elderly, especially polymyaljia rheumatica (PMR) and late-onset rheumatoid arthritis (LORA) is involved in the differential diagnosis. There are several criteria defined for diagnosis. Especially cases of RS3PE that are not associated with malignancy respond well to low-dose steroids. Although the relationship with cancer is known, it is not clear which patients should be screened for cancer. Our aim in this article is to present a patient with RS3PE and to remind physicians dealing with the geriatric population of the existence of RS3PE and to emphasize its importance.