Key result
NMR structure determination of human apoCIII in complex with SDS micelles reveals a necklace of six amphipathic helices, providing a template for exploring its inhibition of lipoprotein lipase.
Population
Human apolipoprotein CIII (apoCIII) in complex with SDS micelles
Design
Preclinical
Authors
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Offers structural template for apoCIII inhibition; leaves open human validation and therapeutic translation.
The first detailed 3D NMR structure of intact human apoCIII in a lipid-bound state provides a structural template for understanding its role in inhibiting lipoprotein lipase and receptor binding.
Gangabadage et al. (2008) studied this question. Human apolipoprotein CIII (apoCIII) was evaluated on Three-dimensional NMR structure and dynamics. NMR structure determination of human apoCIII in complex with SDS micelles reveals a necklace of six amphipathic helices, providing a template for exploring its inhibition of lipoprotein lipase.
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