Key result
ACE G2350A A allele is linked to ~3.6-fold higher hypertension risk in intracerebral hemorrhage.
Why the study?
To evaluate the correlation of ACE G2350A gene polymorphisms with hypertension, brain hematoma volume, level of consciousness, and disease outcome among intracerebral haemorrhage patients.
Is the ACE G2350A gene polymorphism associated with hypertension, brain hematoma volume, level of consciousness, and disease outcome in patients with intracerebral haemorrhage?
Cross-Sectional (n=75)
No
Is the ACE G2350A gene polymorphism associated with hypertension, brain hematoma volume, level of consciousness, and disease outcome in patients with intracerebral haemorrhage?
Provides the first genetic evidence in an Indonesian intracerebral haemorrhage cohort that the A allele of the ACE G2350A polymorphism is associated with hypertension, though not with hematoma volume, consciousness, or clinical outcome.
Should not yet inform ICH management or genotyping; leaves open validation of ACE G2350A hypertension associations in broader populations.
OBJECTIVES: To evaluate the correlation of angiotensin-converting enzyme (ACE) G2350A gene polymorphisms with hypertension, brain hematoma volume (BHV), level of consciousness, and disease outcome among intracerebral haemorrhage (ICH) patients. METHODS: A cross-sectional study was conducted in Zainoel Abidin General Hospital from May 2016 to June 2017. Polymerase chain reaction was used to genotype ACE G2350A gene polymorphisms. BHV was assessed using the ABC/2 volume estimation formula. Level of consciousness was assessed by Glasgow coma scale (GCS). Disease outcome was assessed using Glasgow outcome scale (GOS). Association tests for ACE G2350A genotype in the context of hypertension status, BHV, GCS score, and GOS score in subjects with ICH was analysed by multiple logistic regression. Our analysis determined that the A allele of the ACE G2350A gene polymorphism was significantly associated with a 3.6-fold increase in hypertension; however, this polymorphism was not associated with BHV, level of consciousness, and disease outcome among ICH patients. CONCLUSION: The A allele of the ACE G2350A gene polymorphisms is associated with hypertension among ICH patients.
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Imran et al. (2019) conducted a cross-sectional in Intracerebral haemorrhage (ICH) (n=75). ACE G2350A gene polymorphism (A allele) vs. ACE G2350A G allele was evaluated on Hypertension among intracerebral haemorrhage patients (OR 3.60, 95% CI 0.41-2.43, p=0.046). The A allele of the ACE G2350A gene polymorphism was associated with a 3.60-fold increased risk of hypertension (OR 3.60, p=0.046) among intracerebral haemorrhage patients.
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