Key result
Lipoprotein glycation amplifies oxidative stress and LDL atherogenicity in diabetes and atherosclerosis.
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Glycation of lipoproteins is implicated in the development of the macro- and microvascular complications of diabetes, atherosclerosis in general, and other disease processes including aging. Enhanced glycation may have direct effects, and may also amplify the effects of oxidative stress on lipoproteins. Most studies have examined the effects of glycation of LDL, particularly with respect to its atherogenicity. Other lipoproteins are more difficult to study because their several apolipoproteins, being of varying age, are not uniformly exposed to glucose. Inhibition of the combined stresses of glycation and oxidation towards lipoproteins may have beneficial effects on health.
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Lyons et al. (1997) conducted a review in Diabetes and atherosclerosis. Lipoprotein glycation was evaluated on Macro- and microvascular complications of diabetes and atherogenicity. Lipoprotein glycation amplifies oxidative stress and LDL atherogenicity in diabetes and atherosclerosis, though quantitative clinical estimates were not reported in this review.
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