Why the study?
Does selective intra-arterial blockade with prazosin demonstrate sympathetic vasoconstriction in working skeletal muscles during dynamic exercise in dogs?
Population
Six mongrel dogs instrumented chronically with flow probes on the external iliac arteries of both hindlimbs…
Comparison
Selective alpha 1-adrenergic antagonist prazosin… vs Contralateral iliac artery and baseline before…
Design
Preclinical
Authors
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Hypothesis-generating in dogs; leaves open translation to human exercise physiology or clinical relevance.
Does selective intra-arterial blockade with prazosin demonstrate sympathetic vasoconstriction in working skeletal muscles during dynamic exercise in dogs?
Selective intra-arterial alpha-1 blockade demonstrates that sympathetic vasoconstriction occurs in active skeletal muscles even at high exercise intensities.
Buckwalter et al. (1997) studied this question.
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