Key result
Isoproterenol-induced cardiac hypertrophy enhanced 26S proteasome activities and decreased 20S activities, revealing novel mechanisms for proteasome regulation in the diseased myocardium.
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Does not yet change clinical practice in hypertrophy; hypothesis-generating for proteasome-targeted therapies in human HF.
Drews et al. (2010) studied Cardiac hypertrophy. Isoproterenol was evaluated on Proteasome function, expression, and assembly. Isoproterenol-induced cardiac hypertrophy enhanced 26S proteasome activities and decreased 20S activities, revealing novel mechanisms for proteasome regulation in the diseased myocardium.
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