What question did this study set out to answer?

To establish standardized normal cut-off values for conventional semen parameters that differentiate fertile from subfertile men using receiver operating characteristic (ROC) curve analysis.

June 1, 2001Human ReproductionOpen Access

Semen parameters, including WHO and strict criteria morphology, in a fertile and subfertile population: an effort towards standardization of in-vivo thresholds

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To establish standardized normal cut-off values for conventional semen parameters that differentiate fertile from subfertile men using receiver operating characteristic (ROC) curve analysis.
Analyzed semen parameters from 107 fertile men (partners achieved spontaneous pregnancy within one year and were currently pregnant) and 103 subfertile men presenting with initial sperm counts <20×10⁶/mL.
Calculated diagnostic cut-offs using ROC curve analysis under baseline conditions and recalculated thresholds assuming a 50% prevalence of subfertility in an assisted reproduction setting.
Sperm morphology by WHO criteria was the most discriminative parameter between fertile and subfertile groups with a cut-off of 31% normal spermatozoa, alongside cut-offs of 45% for motility, 8% for acrosome index, and 4% for strict criteria morphology.
Adjusting for a 50% subfertility prevalence shifted the optimal cut-offs to 21% for WHO morphology, 3% for strict criteria morphology, 20% for motility, 3.5 for motility quality, 3% for acrosome index, and 2.09 for teratozoospermia index.

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Implication

Comparative study demonstrates sperm morphology thresholds separating fertile and subfertile men, establishing standardized diagnostic cut-offs for clinical semen evaluation.

Cite This Study

Roelof Menkveld (2001) studied this question.

synapsesocial.com/papers/6a746efcf1e99ff85ab1bfd8 https://doi.org/10.1093/humrep/16.6.1165

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Implication

Comparative study demonstrates sperm morphology thresholds separating fertile and subfertile men, establishing standardized diagnostic cut-offs for clinical semen evaluation.

Semen parameters, including WHO and strict criteria morphology, in a fertile and subfertile population: an effort towards standardization of in-vivo thresholds

Key Points

Discussion

Implication

Cite This Study

Semen parameters, including WHO and strict criteria morphology, in a fertile and subfertile population: an effort towards standardization of in-vivo thresholds

Key Points

Discussion

Implication

Cite This Study

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