What question did this study set out to answer?

To describe a case of severe acute graft rejection and subsequent rescue liver re-transplantation associated with pre-transplant nivolumab therapy for hepatocellular carcinoma.

October 13, 2021Clinical Journal of GastroenterologyOpen Access

Rescue liver re-transplantation after graft loss due to severe rejection in the setting of pre-transplant nivolumab therapy

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Authors

YDYalda Dehghan GSGabriel T. SchnickelUniversity of San Diego MHMojgan HosseiniUniversity of San Diego

Discussion

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Implication

Case report demonstrates rescue liver re-transplantation after severe graft rejection following pre-transplant nivolumab therapy, suggesting durable immunotherapy responses endanger donor organs.

Key Points

To describe a case of severe acute graft rejection and subsequent rescue liver re-transplantation associated with pre-transplant nivolumab therapy for hepatocellular carcinoma.
Clinical case evaluation of a patient receiving pre-transplant PD-1 inhibitor therapy (nivolumab) for hepatocellular carcinoma who underwent liver transplantation.
Diagnostic and histopathological assessment of graft failure leading to emergent rescue re-transplantation.
Pre-transplant nivolumab was followed by severe acute allograft rejection and extensive hepatic necrosis, resulting in the complete loss of the primary graft.
The patient successfully underwent a rescue liver re-transplantation following the initial allograft failure.

Cite This Study

Dehghan et al. (2021) studied this question.

synapsesocial.com/papers/6a746f7bd93df8ecca090bb9 https://doi.org/10.1007/s12328-021-01521-4

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Implication

Case report demonstrates rescue liver re-transplantation after severe graft rejection following pre-transplant nivolumab therapy, suggesting durable immunotherapy responses endanger donor organs.

Rescue liver re-transplantation after graft loss due to severe rejection in the setting of pre-transplant nivolumab therapy

Discussion

Member takes

Implication

Key Points

Cite This Study

Rescue liver re-transplantation after graft loss due to severe rejection in the setting of pre-transplant nivolumab therapy

Discussion

Member takes

Implication

Key Points

Cite This Study

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